Phenotypes associated with this allele

• Allele Symbol: Lgals3^em1Vari
• Allele Name: endonuclease-mediated mutation 1, van Andel Research Institute
• Allele ID: MGI:7464949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgals3^em1Vari/Lgals3^em1Vari	involves: C3H/HeJ * C57BL/6J	MGI:7465132

Genotype
MGI:7465132

hm1

• Allelic Composition: Lgals3^em1Vari/Lgals3^em1Vari
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:329549 )

♀N • normal whole bone strength (max force) and tissue-level strength (max stress)

increased internal diameter of femur ( J:329549 )

♂ • increased marrow cavity diameter of distal femur at age 36 weeks

increased bone mineral density of vertebrae ( J:329549 )

♀ • in L3 at age 36 weeks

increased volumetric bone mineral density ( J:329549 )

♀ • in L3 at age 36 weeks

increased bone volume ( J:329549 )

♂ • increased total cross-section area of distal femur at age 36 weeks

increased compact bone volume ( J:329549 )

♂ • increased cortical cross-section area of distal femur at age 36 weeks

increased trabecular bone volume ( J:329549 )

♀ • in L3 at age 36 weeks

increased bone trabecula number ( J:329549 )

♀ • in L3 at age 36 weeks

decreased bone trabecular spacing ( J:329549 )

♀ • in L3 at age 36 weeks

increased trabecular bone connectivity density ( J:329549 )

♂ • in distal femur at age 36 weeks

increased trabecular bone mass ( J:329549 )

♀ • in L3 at age 36 weeks

increased trabecular bone thickness ( J:329549 )

♀ • in L3 at age 36 weeks

decreased bone strength ( J:329549 )

♂ • reduced tissue-level strength (max stress)

♂ • normal whole bone strength (max force)

limbs/digits/tail

increased internal diameter of femur ( J:329549 )

♂ • increased marrow cavity diameter of distal femur at age 36 weeks

growth/size/body

growth/size/body region phenotype ( J:329549 )

N • normal body weight, percent body fat and areal bone mineral density at age 36 weeks