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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scn9aem1Wlf
endonuclease-mediated mutation 1, Clifford J Woolf
MGI:7466218
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scn9aem1Wlf/Scn9aem1Wlf C57BL/6J-Scn9aem1Wlf MGI:7466284
ht2
 		Scn9aem1Wlf/Scn9a+ C57BL/6J-Scn9aem1Wlf MGI:7466279


Genotype
MGI:7466284
hm1
Allelic
Composition		 Scn9aem1Wlf/Scn9aem1Wlf
Genetic
Background		 C57BL/6J-Scn9aem1Wlf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn9aem1Wlf mutation (0 available); any Scn9a mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:329231 )
• normal dorsal root ganglion (DRG) neuron neurite morphology in vitro
• normal intra-epidermal nerve fiber (IENF) morphology
abnormal nervous system electrophysiology ( J:329231 )
• significantly depolarized resting membrane potential (RMP) in small-diameter dorsal root ganglion (DRG) neurons in vitro
• increased spontaneous firing in small-diameter dorsal root ganglion (DRG) neurons in vitro
• normal input resistance, action potential amplitude, and action potential half width in small-diameter dorsal root ganglion (DRG) neurons in vitro
abnormal action potential ( J:329231 )
• reduced current threshold in small-diameter dorsal root ganglion (DRG) neurons in vitro
increased single cell response intensity ( J:329231 )
• more action potentials in response to 3x threshold current injections in small-diameter dorsal root ganglion (DRG) neurons in vitro

behavior/neurological
behavior/neurological phenotype ( J:329231 )
• normal basal and inflammatory pain behavior




Genotype
MGI:7466279
ht2
Allelic
Composition		 Scn9aem1Wlf/Scn9a+
Genetic
Background		 C57BL/6J-Scn9aem1Wlf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn9aem1Wlf mutation (0 available); any Scn9a mutation (121 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:329231 )
N
• normal dorsal root ganglion (DRG) neuron neurite morphology in vitro
abnormal nervous system electrophysiology ( J:329231 )
• significantly depolarized resting membrane potential (RMP) in small-diameter dorsal root ganglion (DRG) neurons in vitro
• increased spontaneous firing in small-diameter dorsal root ganglion (DRG) neurons in vitro
• normal input resistance, action potential amplitude, and action potential half width in small-diameter dorsal root ganglion (DRG) neurons in vitro
abnormal action potential ( J:329231 )
• reduced current threshold in small-diameter dorsal root ganglion (DRG) neurons in vitro
increased single cell response intensity ( J:329231 )
• more action potentials in response to 3x threshold current injections in small-diameter dorsal root ganglion (DRG) neurons in vitro

behavior/neurological
behavior/neurological phenotype ( J:329231 )
N
• normal basal and inflammatory pain behavior




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory