All Phenotypes Ctnna1<em1Xjz> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctnna1^em1Xjz
endonuclease-mediated mutation 1, Xianjun Zhu
MGI:7466923

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnna1^em1Xjz/Ctnna1^em1Xjz	C57BL/6J-Ctnna1^em1Xjz	MGI:7467106
cn2	Ctnna1^em1Xjz/Ctnna1^tm1Efu Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA	MGI:7467130

Allelic Composition	Ctnna1^em1Xjz/Ctnna1^em1Xjz
Genetic Background	C57BL/6J-Ctnna1^em1Xjz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^em1Xjz mutation (0 available); any Ctnna1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:328283 )

• no mice are born

Allelic Composition	Ctnna1^em1Xjz/Ctnna1^tm1Efu Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^em1Xjz mutation (0 available); any Ctnna1 mutation (133 available)
Ctnna1^tm1Efu mutation (1 available); any Ctnna1 mutation (133 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:328283 )

• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4

hemorrhage ( J:328283 )

• increased blood vessel leakage in retina at age P7 after tamoxifen administration from age P1-P4

vision/eye

abnormal retina development ( J:328283 )

• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4

• increased blood vessel leakage at age P7 after tamoxifen administration from age P1-P4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:328283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24