Phenotypes associated with this allele

• Allele Symbol: Pold1^tyrn
• Allele Name: tiny siren
• Allele ID: MGI:7467225
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pold1^tyrn/Pold1^tyrn	C57BL/6J-Pold1^tyrn	MGI:7467522
ht2	Pold1^tyrn/Pold1^tm1b(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:7467524
cx3	Pold1^tyrn/Pold1^tyrn Tg(Hhex-EGFP)#Rbe/0	involves: C57BL/6 * C57BL/6J * CBA/J	MGI:7467523

Genotype
MGI:7467522

hm1

• Allelic Composition: Pold1^tyrn/Pold1^tyrn
• Genetic Background: C57BL/6J-Pold1^tyrn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased embryonic tissue cell apoptosis ( J:327432 )

• in distal tip of E7.5 embryos

• normal apoptosis in E6.5 embryos

decreased cell proliferation ( J:327432 )

• fewer cells (slower growth rate) in E6.5 and E7 embryos

embryo

embryo phenotype ( J:327432 )

N • normal anterior-posterior (A-P) patterning in E8.5 embryos

N • normal anterior visceral endoderm positioning in E6.5 embryos

increased embryonic tissue cell apoptosis ( J:327432 )

• in distal tip of E7.5 embryos

• normal apoptosis in E6.5 embryos

decreased embryo size ( J:327432 )

• at E8.5

• fewer cells (slower growth rate) in E6.5 and E7 embryos

abnormal embryonic tissue morphology ( J:327432 )

• short A-P axis with flat (instead of U-shaped) E8.5 embryo positioned on posterior side of yolk sac, with head mis-oriented towards the distal tip

growth/size/body

decreased embryo size ( J:327432 )

• at E8.5

• fewer cells (slower growth rate) in E6.5 and E7 embryos

Genotype
MGI:7467524

ht2

• Allelic Composition: Pold1^tyrn/Pold1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:327432 )

• no embryos survive past E7.5

Genotype
MGI:7467523

cx3

• Allelic Composition: Pold1^tyrn/Pold1^tyrn; Tg(Hhex-EGFP)#Rbe/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/J

embryo

embryo phenotype ( J:327432 )

N • normal anterior-posterior (A-P) patterning in E8.5 embryos

N • normal anterior visceral endoderm positioning in E6.5 embryos

abnormal primitive streak elongation ( J:327432 )

• failure of primitive streak to extend to the distal tip in E7.5 embryos

• severe deficiency of allantois mesoderm in E7.5 embryos

• aberrantly positioned anterior definitive endoderm (ADE) and axial mesoderm (AME) in E7.5 embryos

abnormal allantois morphology ( J:327432 )

• severe deficiency of allantois mesoderm in E7.5 embryos