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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phactr1tm1.2Gdo
targeted mutation 1.2, Gillian Douglas
MGI:7469027
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Phactr1tm1.2Gdo/Phactr1tm1.2Gdo 		B6.Cg-Apoetm1Unc Phactr1tm1.2Gdo MGI:7713059


Genotype
MGI:7713059
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Phactr1tm1.2Gdo/Phactr1tm1.2Gdo
Genetic
Background		 B6.Cg-Apoetm1Unc Phactr1tm1.2Gdo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Phactr1tm1.2Gdo mutation (0 available); any Phactr1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:335230 )
N
• systolic blood pressure is normal and mice do not exhibit altered vascular function; isometric tension studies in isolated aortas show that vasoconstriction response to phenylephrine is normal, response to L-NAME is not altered, and endothelial cell-dependent relaxation to acetylcholine is not impacted and no difference is seen in the endothelial cell-independent dilation to sodium nitroprusside
increased heart rate ( J:335230 )
• mice show a small, but significant, increase in heart rate compared to single mutant Apoe homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory