Phenotypes associated with this allele

• Allele Symbol: Phactr1^tm1.2Gdo
• Allele Name: targeted mutation 1.2, Gillian Douglas
• Allele ID: MGI:7469027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Phactr1^tm1.2Gdo/Phactr1^tm1.2Gdo	B6.Cg-Apoe^tm1Unc Phactr1^tm1.2Gdo	MGI:7713059

Genotype
MGI:7713059

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Phactr1^tm1.2Gdo/Phactr1^tm1.2Gdo
• Genetic Background: B6.Cg-Apoe^tm1Unc Phactr1^tm1.2Gdo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:335230 )

N • systolic blood pressure is normal and mice do not exhibit altered vascular function; isometric tension studies in isolated aortas show that vasoconstriction response to phenylephrine is normal, response to L-NAME is not altered, and endothelial cell-dependent relaxation to acetylcholine is not impacted and no difference is seen in the endothelial cell-independent dilation to sodium nitroprusside

increased heart rate ( J:335230 )

• mice show a small, but significant, increase in heart rate compared to single mutant Apoe homozygotes