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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim28tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:7471137
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim28tm1.1Ics/Trim28tm1.1Ics involves: 129S * C57BL/6J MGI:7471236
cn2
 		Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ics/Trim28tm1.1Ipc 		involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J MGI:7471248


Genotype
MGI:7471236
hm1
Allelic
Composition		 Trim28tm1.1Ics/Trim28tm1.1Ics
Genetic
Background		 involves: 129S * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim28tm1.1Ics mutation (0 available); any Trim28 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7471248
cn2
Allelic
Composition		 Tg(Nr5a1-cre)2Klp/0
Trim28tm1.1Ics/Trim28tm1.1Ipc
Genetic
Background		 involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28tm1.1Ics mutation (0 available); any Trim28 mutation (36 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:327192 )
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

reproductive system
abnormal ovarian follicle morphology ( J:327192 )
• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory