Analysis Tools
growth/size/body
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• males show a significantly higher mean lean body mass than wild-type controls
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• males show a significantly higher average body weight than wild-type controls
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homeostasis/metabolism
| N |
• 18-week-old males and females show normal serum ghrelin and leptin levels relative to age-matched wild-type controls
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• males show significantly lower serum ferritin levels than wild-type controls
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• at P75, males show a significantly lower daytime, nighttime, and 24-hr average energy expenditure (Kcal/kg BW/h) in metabolic cages than wild-type males
• after 8h fasting and without access to food, energy expenditure is significantly decreased between 7 and 9 pm and remains lower during the whole measurement due to decreased locomotor activity
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albuminuria
(
J:337480
)
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• males show a significantly higher urine albumin to creatinine ratio than wild-type controls
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renal/urinary system
| N |
• at 12 weeks of age, micro-CT images and histological and ultrastructural analyses show normal kidney volumes and histomorphology with no signs of pathology or metabolic stress
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albuminuria
(
J:337480
)
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• males show a significantly higher urine albumin to creatinine ratio than wild-type controls
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small kidney
(
J:337480
)
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• on a control diet, P0 pups show a significantly lower mean kidney volume than wild-type pups
• however, no differences in kidney volume are observed on a low-iron diet
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endocrine/exocrine glands
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• on a control diet, P0 pups show a significantly lower mean adrenal gland volume than wild-type pups
• however, no differences in adrenal gland volume are observed on a low-iron diet
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adipose tissue
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• on a control diet, P0 pups show a significantly lower mean interscapular brown adipose tissue (IBAT) volume than wild-type pups
• however, no differences in IBAT volume are observed on a low-iron diet
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liver/biliary system
small liver
(
J:337480
)
|
• on a control diet, P0 pups show a significantly lower mean liver volume than wild-type pups
• however, no differences in liver volume are observed on a low-iron diet
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behavior/neurological
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• at P75, males show significantly less food intake (g/kg BW) than wild-type males in metabolic cages during daytime
• however, no differences in nighttime or 24-hr average food intake are observed
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• after 8h fasting and without access to food, mice appear to be less hungry resulting in less intense food-seeking behavior
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• at P75, males show a strong tendency towards fewer nighttime and 24-hr average fine movements (beam breaks/h) in metabolic cages than wild-type males
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• after 8h fasting and without access to food, both fine and Z-activity are significantly decreased at the beginning of nighttime
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hematopoietic system
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• females, but not males, show a significantly lower platelet count than age-matched wild-type controls
• however, many other blood parameters tested are normal in both sexes and no signs of anemia are observed
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embryo
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• when females are kept on a control diet (178.58 mg iron/kg) for 4 weeks before mating, all newborn (P0) pups show a significant size reduction of the kidneys, adrenal glands, interscapular brown adipose tissue, and liver relative to wild-type pups on the control diet; this phenotype is comparable with wild-type pups on a low-iron diet (5.16 mg iron/kg)
• however, pups on a low-iron diet show no further changes in organ size, suggesting that Ccdc198 participates in the scaling of inner organs under adverse conditions (iron deficiency)
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