Phenotypes associated with this allele

• Allele Symbol: Pfn1^tm1Fgi
• Allele Name: targeted mutation 1, Fernando Gianfrancesco
• Allele ID: MGI:7482601
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pfn1^tm1Fgi/Pfn1^+	involves: 129P2/OlaHsd	MGI:7482605

Genotype
MGI:7482605

ht1

• Allelic Composition: Pfn1^tm1Fgi/Pfn1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:335495 )

• abnormal rounding of MEFs during mitosis

abnormal cell nucleus morphology ( J:335495 )

• increased frequency of micronuclei in calvaria mesenchymal cells from newborns

increased cell nucleus count ( J:335495 )

• some trinucleated calvaria mesenchymal cells from newborns and femur growth plate at age 4 months

binucleate ( J:335495 )

• 5x increase in binucleated cells in femur growth plate at age 4 months

abnormal mitotic cytokinesis ( J:335495 )

• in MEFs