Phenotypes associated with this allele

• Allele Symbol: Pla1a^em1Appsc
• Allele Name: endonuclease-mediated mutation 1, Applied StemCell
• Allele ID: MGI:7482743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla1a^em1Appsc/Pla1a^em1Appsc	C57BL/6J-Pla1a^em1Appsc	MGI:7484054

Genotype
MGI:7484054

hm1

• Allelic Composition: Pla1a^em1Appsc/Pla1a^em1Appsc
• Genetic Background: C57BL/6J-Pla1a^em1Appsc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:333902 )

• mice are slightly smaller

enlarged liver ( J:333902 )

homeostasis/metabolism

abnormal interleukin level ( J:333902 )

• mice show reduced IL-7 levels in paw lysate

liver/biliary system

enlarged liver ( J:333902 )

immune system

increased lymphocyte cell number ( J:333902 )

• mice show a slight increase in circulating and lymph node lymphocytes, with CD4+ T cells contributing the most to the increase in lymph nodes

abnormal interleukin level ( J:333902 )

• mice show reduced IL-7 levels in paw lysate

decreased susceptibility to induced arthritis ( J:333902 )

• mice develop less severe mannan-induced psoriatic arthritis symptoms compared to wild-type mice, with reduced incidence of arthritis and lower arthritis score, reduced paw scaling, protection from bone erosions around the distal metacarpophalangeal joints, decreased percentage of CD19+ B cells and CD3+CD8+ T cells in the lymph nodes and increased CD3+ to CD19+ and CD3+CD4+ to CD3+CD8+ ratios, and reduced IL-7 levels

decreased susceptibility to chemically induced skin inflammation ( J:333902 )

• mice show reduced susceptibility to mannan-induced cutaneous inflammation, with reduction of several proinflammatory chemokines/cytokines, including IL-17 in hind paw tissues

hematopoietic system

increased lymphocyte cell number ( J:333902 )

• mice show a slight increase in circulating and lymph node lymphocytes, with CD4+ T cells contributing the most to the increase in lymph nodes

integument

decreased susceptibility to chemically induced skin inflammation ( J:333902 )

• mice show reduced susceptibility to mannan-induced cutaneous inflammation, with reduction of several proinflammatory chemokines/cytokines, including IL-17 in hind paw tissues

skeleton

decreased susceptibility to induced arthritis ( J:333902 )

• mice develop less severe mannan-induced psoriatic arthritis symptoms compared to wild-type mice, with reduced incidence of arthritis and lower arthritis score, reduced paw scaling, protection from bone erosions around the distal metacarpophalangeal joints, decreased percentage of CD19+ B cells and CD3+CD8+ T cells in the lymph nodes and increased CD3+ to CD19+ and CD3+CD4+ to CD3+CD8+ ratios, and reduced IL-7 levels