Phenotypes associated with this allele

• Allele Symbol: Gba1^tm1.1Smoc
• Allele Name: targeted mutation 1.1, Shanghai Model Organisms Center
• Allele ID: MGI:7484418
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gba1^tm1.1Smoc/Gba1^tm1.1Smoc	involves: C57BL/6J	MGI:7484465

Genotype
MGI:7484465

hm1

• Allelic Composition: Gba1^tm1.1Smoc/Gba1^tm1.1Smoc
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal epidermis stratum corneum morphology ( J:325557 )

• more compact and more basophilic

abnormal epidermis stratum granulosum morphology ( J:325557 )

• glycolipid accumulation

abnormal epidermis stratum spinosum morphology ( J:325557 )

• glycolipid accumulation

reddish skin ( J:325557 )

wrinkled skin ( J:325557 )

abnormal skin turgor ( J:325557 )

growth/size/body

decreased body size ( J:325557 )

mortality/aging

postnatal lethality, complete penetrance ( J:325557 )

• mice die within 24 h after birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Gaucher's disease type I		DOID:0110957	OMIM:230800	J:325557