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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr420em1Itok
endonuclease-mediated mutation 1, Kosei Ito
MGI:7484531
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rr420em1Itok/Rr420em1Itok
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:7486536


Genotype
MGI:7486536
cn1
Allelic
Composition		 Rr420em1Itok/Rr420em1Itok
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr420em1Itok mutation (0 available); any Rr420 mutation (0 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased tumor-free survival time ( J:319454 )
• survival time is increased compared to mutant mice wild-type for Rr420

neoplasm
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Rr420
• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3tm1.1Itok

skeleton
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Rr420
• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3tm1.1Itok




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory