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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Puf60tm1.1Kmtsu
targeted mutation 1.1, Kazuyuki Matsushita
MGI:7487995
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Puf60tm1.1Kmtsu/Puf60tm1.1Kmtsu involves: C57BL/6NCrSlc MGI:7488005
cx2
 		Puf60tm1.1Kmtsu/Puf60+
Trp53tm1Sia/Trp53tm1Sia 		involves: C57BL/6NCrlj * C57BL/6NCrSlc * CBA/JNCrlj MGI:7488004


Genotype
MGI:7488005
hm1
Allelic
Composition		 Puf60tm1.1Kmtsu/Puf60tm1.1Kmtsu
Genetic
Background		 involves: C57BL/6NCrSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Puf60tm1.1Kmtsu mutation (0 available); any Puf60 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo

mortality/aging
embryonic lethality, complete penetrance ( J:233347 )
• no mice are present at E9.5




Genotype
MGI:7488004
cx2
Allelic
Composition		 Puf60tm1.1Kmtsu/Puf60+
Trp53tm1Sia/Trp53tm1Sia
Genetic
Background		 involves: C57BL/6NCrlj * C57BL/6NCrSlc * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Puf60tm1.1Kmtsu mutation (0 available); any Puf60 mutation (32 available)
Trp53tm1Sia mutation (10 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:233347 )
N
• unlike Trp53tm1Sia homozygotes

reproductive system

neoplasm
increased T cell derived lymphoma incidence ( J:233347 )
• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes
increased metastatic potential ( J:233347 )
• increased bone marrow invasion compared with Trp53tm1Sia homozygotes

hematopoietic system
increased thymus weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes
increased T cell derived lymphoma incidence ( J:233347 )
• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes
increased spleen weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes
thrombocytopenia ( J:233347 )
• more so than in Trp53tm1Sia homozygotes

growth/size/body
decreased body weight ( J:233347 )
• at time of sacrifice
increased spleen weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes

endocrine/exocrine glands
increased thymus weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes
increased T cell derived lymphoma incidence ( J:233347 )
• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes

respiratory system
respiratory distress ( J:233347 )
• with a loss of movement at time of sacrifice

immune system
increased thymus weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes
increased T cell derived lymphoma incidence ( J:233347 )
• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53tm1Sia homozygotes
increased spleen weight ( J:233347 )
• more so than in Trp53tm1Sia homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory