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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmal1em1Bwu
endonuclease-mediated mutation 1, Baojian Wu
MGI:7488133
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bmal1em1Bwu/Bmal1em1Bwu C57BL/6-Bmal1em1Bwu MGI:7614808


Genotype
MGI:7614808
hm1
Allelic
Composition		 Bmal1em1Bwu/Bmal1em1Bwu
Genetic
Background		 C57BL/6-Bmal1em1Bwu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1em1Bwu mutation (0 available); any Bmal1 mutation (139 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine physiology ( J:340220 )
• colonic expression of Lncucc1 (ulcerative colitis circadian clock long noncoding RNA 1) is downregulated and its diurnal rhythmicity (generated by the central clock protein Bmal1 via an E-box element) is blunted

immune system
abnormal macrophage physiology ( J:340220 )
• serum-shocked bone marrow-derived macrophages (BMDMs) with synchronized circadian cycles show reduced mRNA and rhythmic expression of Lncucc1 and Dbp (D site albumin promoter binding protein, a known Bmal1 target gene)

hematopoietic system
abnormal macrophage physiology ( J:340220 )
• serum-shocked bone marrow-derived macrophages (BMDMs) with synchronized circadian cycles show reduced mRNA and rhythmic expression of Lncucc1 and Dbp (D site albumin promoter binding protein, a known Bmal1 target gene)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory