Phenotypes associated with this allele

• Allele Symbol: Bicra^em2Hzhg
• Allele Name: endonuclease-mediated mutation 2, Honghe Zhang
• Allele ID: MGI:7488660
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bicra^em2Hzhg/Bicra^em2Hzhg	Not Specified	MGI:7543770
ht2	Bicra^em2Hzhg/Bicra^+	Not Specified	MGI:7543771

Genotype
MGI:7543770

hm1

• Allelic Composition: Bicra^em2Hzhg/Bicra^em2Hzhg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:335098 )

• fewer than expected mice are present at E15

• no mice are present at E16.5

cardiovascular system

double outlet right ventricle ( J:335098 )

ventricular septal defect ( J:335098 )

small heart ( J:335098 )

• at E13.5 without a change in proliferation or apoptosis of embryonic myocardial cells

thin ventricular wall ( J:335098 )

• with increased trabecular area

pericardial edema ( J:335098 )

• at E15

abnormal impulse conducting system conduction ( J:335098 )

• abnormal impulse

growth/size/body

embryonic growth retardation ( J:335098 )

decreased embryo size ( J:335098 )

• at E10, E11.5, and E13.5

decreased fetal size ( J:335098 )

• at E15

fetal growth retardation ( J:335098 )

homeostasis/metabolism

pericardial edema ( J:335098 )

• at E15

embryo

embryonic growth retardation ( J:335098 )

decreased embryo size ( J:335098 )

• at E10, E11.5, and E13.5

Genotype
MGI:7543771

ht2

• Allelic Composition: Bicra^em2Hzhg/Bicra⁺
• Genetic Background: Not Specified

growth/size/body

decreased body size ( J:335098 )

decreased body weight ( J:335098 )

homeostasis/metabolism

decreased growth hormone level ( J:335098 )

• within two weeks after birth