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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bicraem3Hzhg
endonuclease-mediated mutation 3, Honghe Zhang
MGI:7488661
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bicraem3Hzhg/Bicraem3Hzhg
Tg(Tnnt2-cre)5Blh/0 		involves: C57BL/6 * DBA/2 MGI:7543773
cn2
 		Bicraem3Hzhg/Bicraem3Hzhg
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:7543774
cn3
 		Bicraem3Hzhg/Bicraem3Hzhg
Tg(Cdh5-cre)7Mlia/0 		involves: FVB/N MGI:7543772


Genotype
MGI:7543773
cn1
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
Tg(Tnnt2-cre)5Blh/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (55 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:335098 )
N
• mice exhibit normal embryonic survival

cardiovascular system
cardiovascular system phenotype ( J:335098 )
N
• mice exhibit normal cardiac phenotype




Genotype
MGI:7543774
cn2
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (55 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
double outlet right ventricle ( J:335098 )
• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum
ventricular septal defect ( J:335098 )
• at E15 and E16.5 without abnormal thickness of the ventricular wall and ventricular septum
decreased cardiac output ( J:335098 )
• lower right ventricular output
abnormal coronary circulation ( J:335098 )
• transventricular septal flow
decreased heart right ventricle muscle contractility ( J:335098 )
• reduced right ventricular output stroke volume and ejection fraction

growth/size/body
decreased body size ( J:335098 )
• at P7

muscle
decreased heart right ventricle muscle contractility ( J:335098 )
• reduced right ventricular output stroke volume and ejection fraction




Genotype
MGI:7543772
cn3
Allelic
Composition		 Bicraem3Hzhg/Bicraem3Hzhg
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation (0 available); any Bicra mutation (55 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:335098 )
• mice exhibit normal embryonic survival

cardiovascular system
cardiovascular system phenotype ( J:335098 )
• mice exhibit normal cardiac phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory