All Phenotypes Atp6ap2<em1Nira> MGI Mouse

adipose tissue

decreased epididymal fat pad weight ( J:324587 )

behavior/neurological

behavior/neurological phenotype ( J:324587 )

N	• normal food and water intake and energy expenditure

cardiovascular system

cardiovascular system phenotype ( J:324587 )

• normal mesenteric artery resting internal diameter, vessel length, maximal KCl-evoked tension development during L-max determination, and resting tension at L-max

• normal cardiac output, ejection fraction, fractional shortening, stroke volume, end-systolic and end-diastolic left ventricular volume, and E/A

• normal cardiomyocyte, cardiac tissue and aorta morphology

• normal cardiac output, ejection fraction, fractional shortening, left ventricular mass, and E/A after ANG2 infusion

• normal mesenteric artery KCl- or phenylephrine-induced vasocontraction

• normal sodium nitroprusside-evoked vasodilation in mesenteric arteries after precontraction using phenylephrine

increased heart left ventricle weight ( J:324587 )

abnormal cardiovascular system physiology ( J:324587 )

• increased left ventricular end-diastolic volume after ANG2 infusion

• greater acetylcholine-evoked vasorelaxation in arteries after precontraction using phenylephrine

increased cardiac stroke volume ( J:324587 )

• after ANG2 infusion

decreased systemic arterial systolic blood pressure ( J:324587 )

decreased susceptibility to hypertension ( J:324587 )

• attenuated hypertensive response to ANG2 infusion

cellular

cellular phenotype ( J:324587 )

N	• no lysosomal acidification in heart, kidney and aorta

growth/size/body

growth/size/body region phenotype ( J:324587 )

N	• normal heart, kidney and aorta morphology • normal body fat and fluid mass • normal kidney-to-body weight and heart-to-body weight ratios after ANG2 infusion

increased lean body mass ( J:324587 )

decreased body weight ( J:324587 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:324587 )

• normal plasma electrolyte and blood gas levels

• normal food and water intake and energy expenditure

• normal urine volume and urine aldosterone, Na+ and K+ excretion

• normal plasma renin and aldosterone levels

• normal food and water intake after ANG2 infusion

• normal urine osmolality and AVP, Na+ and K+ excretion after ANG2 infusion

• normal blood urea nitrogen after ANG2 infusion

decreased circulating angiotensinogen level ( J:324587 )

liver/biliary system

decreased liver weight ( J:324587 )

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:324587 )

• no ANG2 infusion-induced renal tubular vacuolation

• reduced ANG2 infusion-induced urinary albumin excretion

• reduced ANG2 infusion-induced urinary thiobarbituric acid reactive substances excretion

renal/urinary system

decreased kidney weight ( J:324587 )

decreased urine output ( J:324587 )

• after ANG2 infusion

reproductive system

male infertility ( J:324587 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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