Phenotypes associated with this allele

• Allele Symbol: Eif4e^{Tn(pb-Act-RFP)1Xwu}
• Allele Name: transposon insertion 1, Xiaohui Wu
• Allele ID: MGI:7490226
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif4e^Tn(pb-Act-RFP)1Xwu/Eif4e^Tn(pb-Act-RFP)1Xwu	involves: FVB/NJ	MGI:7738546
ht2	Eif4e^Tn(pb-Act-RFP)1Xwu/Eif4e^+	involves: FVB/NJ	MGI:7738547

Genotype
MGI:7738546

hm1

• Allelic Composition: Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e^{Tn(pb-Act-RFP)1Xwu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:308879 )

• fewer than expected homozygous embryos are detected at the four- to eight-cell stage

• however, most homozygous embryos are able to form morphological blastocysts

embryonic lethality between implantation and somite formation, complete penetrance ( J:308879 )

• no homozygous embryos are produced from heterozygous cross-matings, with lethality occurring soon after implantation; no viable homozygotes are detected by E7.5

• survival to the blastocyst stage is possibly due to the persistence of maternal protein within the early embryo

embryo

abnormal embryonic epiblast morphology ( J:308879 )

• in vitro, blastocysts generally fail to produce a normal Oct3/4+ pluripotent epiblast after 96 h of culture

reproductive system

abnormal embryo implantation ( J:308879 )

• in vitro, blastocysts frequently show reduced expansion and either fail to produce outgrowths or produce outgrowths of a smaller size relative to heterozygous or wild-type embryos

homeostasis/metabolism

abnormal translation ( J:308879 )

• embryos derived from heterozygous crosses have variable but generally lower levels of protein synthesis than embryos derived from wild-type crosses

cellular

abnormal translation ( J:308879 )

• embryos derived from heterozygous crosses have variable but generally lower levels of protein synthesis than embryos derived from wild-type crosses

Genotype
MGI:7738547

ht2

• Allelic Composition: Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e⁺
• Genetic Background: involves: FVB/NJ

growth/size/body

decreased body weight ( J:308879 )

• at 4 weeks of age, the body weight of heterozygous pups resulting from heterozygous cross-matings is significantly lower than that of wild-type littermates

embryo

embryo phenotype ( J:308879 )

N • heterozygous embryos develop normally past the implantation stage and mice are viable