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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk26tm2.1Zzh
targeted mutation 2.1, Zhaocai Zhou
MGI:7490341
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Stk26tm2.1Zzh/Stk26tm2.1Zzh involves: 129P2/OlaHsd * C57BL/6 MGI:7491699
cn2
 		Lgr5tm1(cre/ERT2)Cle/Lgr5+
Stk26tm2.1Zzh/Stk26tm2.1Zzh 		involves: 129P2/OlaHsd * C57BL/6 MGI:7491700
cn3
 		Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh 		involves: 129P2/OlaHsd * C57BL/6 MGI:7491701
cn4
 		Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh 		involves: C57BL/6 * SJL MGI:7491702


Genotype
MGI:7491699
cn1
Allelic
Composition		 Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal intestinal goblet cell morphology ( J:322311 )
• reduced number in small intestines
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of crypt cells

digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:322311 )
• reduced number in small intestines
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of crypt cells

endocrine/exocrine glands




Genotype
MGI:7491700
cn2
Allelic
Composition		 Lgr5tm1(cre/ERT2)Cle/Lgr5+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of intestinal stem cells after 5-fluoruracil (5-FU)-induced killing of proliferating intestinal cells

digestive/alimentary system
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of intestinal stem cells after 5-fluoruracil (5-FU)-induced killing of proliferating intestinal cells




Genotype
MGI:7491701
cn3
Allelic
Composition		 Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9em1(cre/ERT2)Tchn mutation (1 available); any Sox9 mutation (33 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal enterocyte proliferation ( J:322311 )
• reduced number of intestinal stem cells and proliferation of intestinal cells

digestive/alimentary system
abnormal enterocyte proliferation ( J:322311 )
• reduced number of intestinal stem cells and proliferation of intestinal cells

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:322311 )
• reduced number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas

neoplasm
decreased incidence of tumors by chemical induction ( J:322311 )
• reduced number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas




Genotype
MGI:7491702
cn4
Allelic
Composition		 Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9em1(cre/ERT2)Tchn mutation (1 available); any Sox9 mutation (33 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis

neoplasm
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory