Analysis Tools
cardiovascular system
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• endothelial cells in the retina show a decrease in filopodia number, suggesting decreased motility of endothelial sprouts
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• P5 retinal vasculature shows a slight, but significant, decrease in vascular outgrowth
• however, no differences in retinal endothelial cell proliferation or in density of retinal vasculature are seen and no difference in endothelial cell sprout number in retinas is seen, indicating normal tip-stalk cell specification
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• mice inoculated with Lewis lung carcinoma cells or melanoma cells on the flanks show a 30% decrease in vessel density, however no differences in tumor growth are seen, indicating decreased tumor angiogenesis
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• P5 retinal vasculature shows a slight but significant decrease in vascular outgrowth, indicating impaired angiogenesis
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• endothelial cells are less responsive to VEGF-A
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• VEGF-A165-induced vascular permeability is reduced
• however, histamine and VEGF-A121 vascular permeability is undistinguishable from wild-type mice
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cellular
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• mice show reduced polymorphonuclear leukocyte extravasation at both 2 and 4 hours after interleukin-1beta-induced inflammation of the peritoneum
• the decreased leukocyte extravasation is due to reduced transmigration and not rolling or adhesion to the epithelium
• however, no structural differences in adherens and tight junctions are seen
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hematopoietic system
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• mice show reduced polymorphonuclear leukocyte extravasation at both 2 and 4 hours after interleukin-1beta-induced inflammation of the peritoneum
• the decreased leukocyte extravasation is due to reduced transmigration and not rolling or adhesion to the epithelium
• however, no structural differences in adherens and tight junctions are seen
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homeostasis/metabolism
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• following middle cerebral artery occlusion to induce ischemic stroke, mice exhibit a 50% decrease in edema-corrected lesion volumes and the affected hemisphere space-occupying effect attributable to brain edema
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immune system
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• mice show reduced polymorphonuclear leukocyte extravasation at both 2 and 4 hours after interleukin-1beta-induced inflammation of the peritoneum
• the decreased leukocyte extravasation is due to reduced transmigration and not rolling or adhesion to the epithelium
• however, no structural differences in adherens and tight junctions are seen
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neoplasm
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• mice inoculated with Lewis lung carcinoma cells or melanoma cells on the flanks show a 30% decrease in vessel density, however no differences in tumor growth are seen, indicating decreased tumor angiogenesis
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nervous system
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• following middle cerebral artery occlusion to induce ischemic stroke, mice exhibit a 50% decrease in edema-corrected lesion volumes and the affected hemisphere space-occupying effect attributable to brain edema
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vision/eye
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• P5 retinal vasculature shows a slight, but significant, decrease in vascular outgrowth
• however, no differences in retinal endothelial cell proliferation or in density of retinal vasculature are seen and no difference in endothelial cell sprout number in retinas is seen, indicating normal tip-stalk cell specification
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