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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slfn4tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:7493861
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+ 		involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster MGI:7531280


Genotype
MGI:7531280
cn1
Allelic
Composition		 Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster
Cell Lines EPD0746_4_G08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (49 available)
Slfn4tm1c(EUCOMM)Wtsi mutation (0 available); any Slfn4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal stomach mucosa morphology ( J:337060 )
• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H+, K+ -ATPase+ parietal cells

immune system
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls
abnormal interleukin level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
abnormal tumor necrosis factor level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls
decreased susceptibility to bacterial infection ( J:337060 )
• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls

homeostasis/metabolism
abnormal interleukin level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
abnormal tumor necrosis factor level ( J:337060 )
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

hematopoietic system
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:337060 )
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory