Analysis Tools
nervous system
| N |
• mice show no significant differences in the paired pulse ratio (PPR) recorded from parvalbumin-positive inhibitory interneurons (PV-INs), suggesting normal presynaptic release probabilities; moreover, the AMPA/NMDA ratio is normal in PV-INs
|
|
• mice exhibit a smaller median Psd-95-GFP puncta area per dendritic region in PV-INs than control mice
• however, the density of Psd-95-GFP puncta (a proxy of glutamatergic synapse density) is normal in PV-INs
|
|
• analysis of visually evoked gamma oscillations in the primary visual cortex (V1) showed that, when mice are presented with a gray screen, the gray/black screen ratio of both mean and peak 55-65 Hz activity is significantly higher than that in control mice, indicating increased power in the narrowband gamma frequency
|
|
• mEPSC frequency is severely reduced in parvalbumin-positive inhibitory interneurons (PV-INs) in the primary visual cortex (V1), as recorded at -70 mV in the presence of TTX and gabazine
• however, mEPSC amplitude, half-maximal rise time and half-maximal decay time in PV-INs are equivalent to those in control mice
|
|
• mice exhibit decreased glutamatergic synaptic activity in PV-INs
|
behavior/neurological
| N |
• both sexes show no significant changes in short-term spatial memory and contextual fear conditioning tests relative to control mice
|
|
• following injection of glutamate N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, mice show a significantly greater increase in locomotor activity than similarly treated controls, as determined by the total number of infrared beam breaks in an open field arena during the 30-60 min period post-injection
|
|
• both sexes exhibit significantly more rearing events during a 30-min period of open field exploration, indicating an increased exploratory drive
|
|
• both sexes make significantly more beam breaks in the center region of an open field arena during the first 5 min of exploration, suggesting reduced anxiety
(J:337062)
• in the elevated plus maze (EPM) test, mice exhibit a significantly higher ratio of entries to the extreme end of the open arm vs. entries into the closed arm and spend significantly less time freezing during the 5-min test
(J:337062)
|
|
 |
• in the hole-board test, male -- but not female -- mice make significantly more nose pokes than controls during a 3-min session
(J:337062)
• in the marble burying task, male -- but not female -- mice bury significantly fewer marbles than controls
(J:337062)
|
|
• both sexes spend significantly less time freezing on the elevated plus maze apparatus during the 5 min test
|
|
• both sexes exhibit significantly more rearing events during a 30-min period of open field exploration, indicating an increased exploratory drive
• however, locomotor activity is normal, as determined by the total number of infrared beam breaks in an open field arena during a 90-min period in the dark or a 30-min period in the light
|
