All Phenotypes Pabir1<em1.1Yhua> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pabir1^em1.1Yhua
endonuclease-mediated mutation 1.1, Ying Huang
MGI:7494133

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pabir1^em1.1Yhua/Pabir1^em1.1Yhua Myh6^em2(cre)Smoc/Myh6⁺	involves: C57BL/6 * C57BL/6J	MGI:7547011
cn2	Pabir1^em1.1Yhua/Pabir1^em1.1Yhua Nkx2-5^em1(icre)Gpt/Nkx2-5⁺	involves: C57BL/6 * C57BL/6JGpt	MGI:7547002

Allelic Composition	Pabir1^em1.1Yhua/Pabir1^em1.1Yhua Myh6^em2(cre)Smoc/Myh6⁺
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh6^em2(cre)Smoc mutation (0 available); any Myh6 mutation (206 available)
Pabir1^em1.1Yhua mutation (0 available); any Pabir1 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:337007 )

cardiovascular system

decreased heart weight ( J:337007 )

• the heart weight to body weight is decreased indicating a decrease in heart weight

decreased cardiac stroke volume ( J:337007 )

decreased cardiac muscle contractility ( J:337007 )

• mice show impaired cardiac function, as indicated by decreased heart weight ratio, percentages of ejection fraction and fractional shortening, and stroke volume

abnormal heart echocardiography feature ( J:337007 )

• echocardiography indicates increased left ventricular internal diameter in systole (LVIDs), reduced interventricular thickness in diastole (IVSd) and in systole (IVSs), reduced ejection fraction and fractional shortening, and reduced stroke volume

muscle