Phenotypes associated with this allele

• Allele Symbol: Pabir1^em2Yhua
• Allele Name: endonuclease-mediated mutation 2, Ying Huang
• Allele ID: MGI:7494165
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pabir1^em2Yhua/Pabir1^+	involves: 129/SvJ * C57BL/6	MGI:7546998

Genotype
MGI:7546998

ht1

• Allelic Composition: Pabir1^em2Yhua/Pabir1⁺
• Genetic Background: involves: 129/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:337007 )

• number of embryos decrease gradually from E9.5 to E11.5 and are absent on E12.5 due to reabsorption

growth/size/body

embryonic growth retardation ( J:337007 )

• E9.5 embryos show severe growth retardation and are smaller

cardiovascular system

abnormal vitelline vasculature morphology ( J:337007 )

• E9.6 embryos show absence of large vessel formation in yolk sac

abnormal atrium myocardium morphology ( J:337007 )

• E9.5 embryos show defects of atrial and ventricular chambers with thinner myocardial walls

abnormal ventricle myocardium morphology ( J:337007 )

• E9.5 embryos show defects of atrial and ventricular chambers with thinner myocardial walls

thin myocardium ( J:337007 )

• in E9.5 embryos

abnormal pericardial cavity morphology ( J:337007 )

• E9.5 embryos exhibit enlargement of the pericardial cavity

pericardial effusion ( J:337007 )

• pericardial effusion in E9.5 embryos

embryo

abnormal embryo development ( J:337007 )

• E9.5 embryos show multiple structural malformations

• E8.5 embryos show partial developmental delays, such as smaller head folds and reduced extra-embryonic tissues

abnormal embryo turning ( J:337007 )

• E9.5 embryos exhibit turning defects

embryonic growth retardation ( J:337007 )

• E9.5 embryos show severe growth retardation and are smaller

abnormal cephalic neural fold morphology ( J:337007 )

• E9.5 embryos exhibit open anterior neural folds

abnormal somite development ( J:337007 )

• E9.5 embryos exhibit defects in somite formation

abnormal extraembryonic tissue morphology ( J:337007 )

• E8.5 embryos show reduced extraembryonic tissues

abnormal vitelline vasculature morphology ( J:337007 )

• E9.6 embryos show absence of large vessel formation in yolk sac

homeostasis/metabolism

pericardial effusion ( J:337007 )

• pericardial effusion in E9.5 embryos

muscle

abnormal atrium myocardium morphology ( J:337007 )

• E9.5 embryos show defects of atrial and ventricular chambers with thinner myocardial walls

abnormal ventricle myocardium morphology ( J:337007 )

• E9.5 embryos show defects of atrial and ventricular chambers with thinner myocardial walls

thin myocardium ( J:337007 )

• in E9.5 embryos