Phenotypes associated with this allele

• Allele Symbol: Tg(Nes-Reln)#Cur
• Allele Name: transgene insertion, Tom Curran
• Allele ID: MGI:7494373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chd7^tm2c(EUCOMM)Wtsi/Chd7^tm2c(EUCOMM)Wtsi Tg(Atoh1-cre)1Bfri/0 Tg(Nes-Reln)#Cur/0	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA * FVB	MGI:7494375

Genotype
MGI:7494375

cn1

• Allelic Composition: Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}; Tg(Atoh1-cre)1Bfri/0; Tg(Nes-Reln)#Cur/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA * FVB
• Cell Lines: EPD0019_1_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:242933 )

N • overexpression of Reln fully corrects the decrease in granule cell precursors seen in mutant mice without the Reln transgene at P1

abnormal cerebellar lobule formation ( J:242933 )

♂ • overexpression of Reln rescues the decrease in lobule size for lobules VI-VII in female but not male mice

♂ • no difference in Reln expression levels are seen between males and females