All Phenotypes Adad2<em1Osb> MGI Mouse

reproductive system phenotype ( J:337548 )

N	• male mice show no significant differences in testis-to-body-weight ratio relative to wild-type controls

decreased male germ cell number ( J:337548 )

• numbers of elongated spermatids are reduced

abnormal spermatogenesis ( J:337548 )

• spermatogenesis is generally normal until the early round spermatid stage

abnormal sperm head morphology ( J:337548 )

• step 9-16 spermatids show abnormal head morphology

abnormal spermatid morphology ( J:337548 )

• testis histology showed occasional binucleated early round spermatids

abnormal spermatocyte morphology ( J:337548 )

• pachytene spermatocytes show a marked reduction in the numbers of RNF17 granules

abnormal male meiosis ( J:337548 )

• binucleated round spermatids are occasionally detected in the seminiferous tubules, indicating disrupted meiotic cytokinesis

abnormal spermiogenesis ( J:337548 )

• low numbers of immature or deformed sperm cells are detected in extracts of cauda epididymides, indicating impaired spermiogenesis

• males show aberrant migration of elongating spermatids in stage VI-VIII seminiferous tubules, delayed detachment of elongated spermatids from the germinal epithelium in stage IX-X tubules, abnormal head morphology in step 9-16 spermatids, and reduced numbers of elongated spermatids

male infertility ( J:337548 )

• male mice bred with wild-type females for 8 weeks fail to sire any offspring