reproductive system
• elongated spermatids are rarely found in the seminiferous tubules
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• multinucleated cysts containing degenerated round spermatids are observed
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• testis weight is significantly lower than that in age-matched heterozygous controls
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• spermatogenesis is generally normal until the early round spermatid stage
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• elongated spermatids are rarely found in the seminiferous tubules, and multinucleated cysts containing degenerated round spermatids are observed
• at ~P24 (around the onset of spermiogenesis) cluster-derived pachytene PIWI-interacting RNA (piRNAs) are reduced while transposon-derived (intron-, SINE-, LINE-, and LTR-derived) piRNAs are increased in the testes
• both MILI-bound and MIWI-bound pachytene cluster-derived piRNAs are reduced
• LINE-1 expression is not detected in testes, indicating that arrested spermiogenesis is not due to LINE-1 derepression
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• male mice bred with wild-type females for 8 weeks fail to sire any offspring
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cellular
• elongated spermatids are rarely found in the seminiferous tubules
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• multinucleated cysts containing degenerated round spermatids are observed
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endocrine/exocrine glands
• testis weight is significantly lower than that in age-matched heterozygous controls
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