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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adad2em2Osb
endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
MGI:7495733
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adad2em2Osb/Adad2em2Osb C57BL/6J-Adad2em2Osb MGI:7509464


Genotype
MGI:7509464
hm1
Allelic
Composition
Adad2em2Osb/Adad2em2Osb
Genetic
Background
C57BL/6J-Adad2em2Osb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adad2em2Osb mutation (0 available); any Adad2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• elongated spermatids are rarely found in the seminiferous tubules
• multinucleated cysts containing degenerated round spermatids are observed
• testis weight is significantly lower than that in age-matched heterozygous controls
• spermatogenesis is generally normal until the early round spermatid stage
• elongated spermatids are rarely found in the seminiferous tubules, and multinucleated cysts containing degenerated round spermatids are observed
• at ~P24 (around the onset of spermiogenesis) cluster-derived pachytene PIWI-interacting RNA (piRNAs) are reduced while transposon-derived (intron-, SINE-, LINE-, and LTR-derived) piRNAs are increased in the testes
• both MILI-bound and MIWI-bound pachytene cluster-derived piRNAs are reduced
• LINE-1 expression is not detected in testes, indicating that arrested spermiogenesis is not due to LINE-1 derepression
• male mice bred with wild-type females for 8 weeks fail to sire any offspring

cellular
• elongated spermatids are rarely found in the seminiferous tubules
• multinucleated cysts containing degenerated round spermatids are observed

endocrine/exocrine glands
• testis weight is significantly lower than that in age-matched heterozygous controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory