Analysis Tools
behavior/neurological
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• latency to fall in the inverted wire hang test is much shorter even at 3 weeks of age
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growth/size/body
nervous system
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• at 16 weeks of age the neuromuscular junction of the assessed skeletal muscle had the majority of junctions denervated and an additional number partially denervated
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• By 8 weeks 13% reduction in the sensory branch and 34% reduction in the motor branch of the femoral nerve
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• sciatic nerve cell conduction velocity is significantly reduce in homozygotes and reduced to an intermediate level in heterozygotes, which is distinct from the em1Cx allele which does not show this reduction
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muscle
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• hindlimb wasting and decreased body weight with motor function deficits evident by 3 weeks
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Charcot-Marie-Tooth disease axonal type 2S | DOID:0110171 |
OMIM:616155 |
J:337488 | |
