Phenotypes associated with this allele

• Allele Symbol: Del(7Saa1-Saa2)1Itl
• Allele Name: deletion, Chr 7, inGenious Targeting Laboratory
• Allele ID: MGI:7496047
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7Saa1-Saa2)1Itl/Del(7Saa1-Saa2)1Itl	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:7496048

Genotype
MGI:7496048

hm1

• Allelic Composition: Del(7Saa1-Saa2)1Itl/Del(7Saa1-Saa2)1Itl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating phospholipid level ( J:165605 )

• following LPS treatment

abnormal cholesterol homeostasis ( J:165605 )

• the increased size of acute-phase HDL in LPS-treated mice is associated with an increased content of surface lipids, particularly phospholipids but not surface proteins, compared with similarly treated wild-type mice

increased circulating cholesterol level ( J:165605 )

• in male mice treated with LPS unlike similarly treated wild-type male mice

• however, female mice exhibit a normal increase in serum cholesterol levels following LPS treatment