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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bod1lem1Bltn
endonuclease-mediated mutation 1, Simon Boulton
MGI:7506247
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bod1lem1Bltn/Bod1lem1Bltn
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:7540616
cn2
 		Bod1lem1Bltn/Bod1lem1Bltn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6J * C57BL/6NTac MGI:7540619


Genotype
MGI:7540616
cn1
Allelic
Composition		 Bod1lem1Bltn/Bod1lem1Bltn
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bod1lem1Bltn mutation (0 available); any Bod1l mutation (111 available)
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:337726 )
• pre-immune IgG in the serum
decreased IgG1 level ( J:337726 )
• anti-NP27 IgG1 following immunization

hematopoietic system
decreased IgG level ( J:337726 )
• pre-immune IgG in the serum
decreased IgG1 level ( J:337726 )
• anti-NP27 IgG1 following immunization




Genotype
MGI:7540619
cn2
Allelic
Composition		 Bod1lem1Bltn/Bod1lem1Bltn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bod1lem1Bltn mutation (0 available); any Bod1l mutation (111 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:337726 )
• reduced in CD19+ B cells isolated from tamoxifen-treated mice and treated with IL4 and LPS, LPS, or IL4 and alphaCD40
decreased IgG1 level ( J:337726 )
• in CD19+ B cells isolated from tamoxifen-treated mice and treated with IL4 and LPS, LPS, or IL4 and alphaCD40

hematopoietic system
abnormal class switch recombination ( J:337726 )
• reduced in CD19+ B cells isolated from tamoxifen-treated mice and treated with IL4 and LPS, LPS, or IL4 and alphaCD40
decreased IgG1 level ( J:337726 )
• in CD19+ B cells isolated from tamoxifen-treated mice and treated with IL4 and LPS, LPS, or IL4 and alphaCD40




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory