Phenotypes associated with this allele

• Allele Symbol: Dnmt1^em2Jiemw
• Allele Name: endonuclease-mediated mutation 2, Jiemin Wong
• Allele ID: MGI:7506781
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt1^em2Jiemw/Dnmt1^em2Jiemw	C57BL/6-Dnmt1^em2Jiemw	MGI:7506875
ht2	Dnmt1^em2Jiemw/Dnmt1^+	C57BL/6-Dnmt1^em2Jiemw	MGI:7506876

Genotype
MGI:7506875

hm1

• Allelic Composition: Dnmt1^em2Jiemw/Dnmt1^em2Jiemw
• Genetic Background: C57BL/6-Dnmt1^em2Jiemw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:310870 )

• embryos die between E10.5 and E11

Genotype
MGI:7506876

ht2

• Allelic Composition: Dnmt1^em2Jiemw/Dnmt1⁺
• Genetic Background: C57BL/6-Dnmt1^em2Jiemw

behavior/neurological

impaired spatial learning ( J:310870 )

• longer latency, fewer number of platform crossings and less time spent in target quadrant in Morris water maze test

• normal swimming speed in Morris water maze test

abnormal spatial reference memory ( J:310870 )

• higher error ratio in radial 8-arm maze test

abnormal spatial working memory ( J:310870 )

• higher error ratio in radial 8-arm maze test

abnormal response to novel object ( J:310870 )

• no difference in time spent with novel object

cellular

increased neuron apoptosis ( J:310870 )

• in hippocampus

nervous system

increased neuron apoptosis ( J:310870 )

• in hippocampus

decreased neuron number ( J:310870 )

• reduced number of immature DCX+ neurons

decreased neuronal stem cell self-renewal ( J:310870 )

• reduced proliferation of adult NSCs