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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		2310011J03Rikem1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:7507200
Summary 2 genotypes


Genotype
MGI:7628893
hm1
Allelic
Composition		 2310011J03Rikem1(IMPC)Mbp/2310011J03Rikem1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-2310011J03Rikem1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310011J03Rikem1(IMPC)Mbp mutation (1 available); any 2310011J03Rik mutation (7 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

2310011J03Rikem1(IMPC)Mbp/2310011J03Rikem1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
decreased egg cylinder size ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5




Genotype
MGI:7628892
ht2
Allelic
Composition		 2310011J03Rikem1(IMPC)Mbp/2310011J03Rik+
Genetic
Background		 C57BL/6NCrl-2310011J03Rikem1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310011J03Rikem1(IMPC)Mbp mutation (1 available); any 2310011J03Rik mutation (7 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory