Phenotypes associated with this allele

• Allele Symbol: Csrp3^tm1.1Kage
• Allele Name: targeted mutation 1.1, Katja Gehmlich
• Allele ID: MGI:7509517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csrp3^tm1.1Kage/Csrp3^tm1.1Kage	involves: C57BL/6 * C57BL/6J * C57BL/6N * SJL	MGI:7509544

Genotype
MGI:7509544

hm1

• Allelic Composition: Csrp3^tm1.1Kage/Csrp3^tm1.1Kage
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:307893 )

♂ • increased heart weight to tibia length ratio

increased heart left ventricle size ( J:307893 )

♂ • greater end-diastolic dimension and smaller fractional shortening

increased heart left ventricle weight ( J:307893 )

♂

decreased heart left ventricle muscle contractility ( J:307893 )

♂ • decreased left ventricle dP/dt and reduced contractile reserve in response to beta-adrenergic stimulation

abnormal cardiac muscle relaxation ( J:307893 )

♂ • increased relaxation constant Tau

muscle

decreased heart left ventricle muscle contractility ( J:307893 )

♂ • decreased left ventricle dP/dt and reduced contractile reserve in response to beta-adrenergic stimulation

abnormal cardiac muscle relaxation ( J:307893 )

♂ • increased relaxation constant Tau

growth/size/body

increased heart weight ( J:307893 )

♂ • increased heart weight to tibia length ratio

mortality/aging

mortality/aging ( J:307893 )

N • viable and normal lifespan

embryo

embryo phenotype ( J:307893 )

N • viable

reproductive system

reproductive system phenotype ( J:307893 )

N • fertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy		DOID:11984		J:307893