Phenotypes associated with this allele

• Allele Symbol: Myh6^em2(cre)Smoc
• Allele Name: endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• Allele ID: MGI:7510097
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pabir1^em1.1Yhua/Pabir1^em1.1Yhua Myh6^em2(cre)Smoc/Myh6^+	involves: C57BL/6 * C57BL/6J	MGI:7547011

Genotype
MGI:7547011

cn1

• Allelic Composition: Pabir1^em1.1Yhua/Pabir1^em1.1Yhua; Myh6^em2(cre)Smoc/Myh6⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:337007 )

cardiovascular system

decreased heart weight ( J:337007 )

• the heart weight to body weight is decreased indicating a decrease in heart weight

decreased cardiac stroke volume ( J:337007 )

decreased cardiac muscle contractility ( J:337007 )

• mice show impaired cardiac function, as indicated by decreased heart weight ratio, percentages of ejection fraction and fractional shortening, and stroke volume

abnormal heart echocardiography feature ( J:337007 )

• echocardiography indicates increased left ventricular internal diameter in systole (LVIDs), reduced interventricular thickness in diastole (IVSd) and in systole (IVSs), reduced ejection fraction and fractional shortening, and reduced stroke volume

muscle

decreased cardiac muscle contractility ( J:337007 )

• mice show impaired cardiac function, as indicated by decreased heart weight ratio, percentages of ejection fraction and fractional shortening, and stroke volume