Phenotypes associated with this allele

• Allele Symbol: Kctd19^em1Fcw
• Allele Name: endonuclease-mediated mutation 1, Fengchao Wang
• Allele ID: MGI:7511806
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kctd19^em1Fcw/Kctd19^em1Fcw	Not Specified	MGI:7640171

Genotype
MGI:7640171

hm1

• Allelic Composition: Kctd19^em1Fcw/Kctd19^em1Fcw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased male germ cell apoptosis ( J:338159 )

♂ • apoptosis is increased in testes; most apoptotic cells are metaphase spermatocytes in stage XI-XII tubules, and some in stage I-III tubules

abnormal spermatogenesis ( J:338159 )

♂ • spermatogenesis is arrested at meiotic metaphase and no round or elenogated spermatids are seen in the seminiferous tubules

azoospermia ( J:338159 )

♂ • no mature spermatozoa are seen in the cauda epididymis

abnormal male meiosis ( J:338159 )

♂ • spermatocytes show chromosome misalignment on the metaphase plate (metaphase I)

♂ • meiotic cell cycle is delayed from early to mid/late pachytene from P14 to P18

♂ • however, no obvious alternations are seen in double-strand DNA break repair, synapse formation, or crossover formation in spermatocytes

male infertility ( J:338159 )

♂

cellular

azoospermia ( J:338159 )

♂ • no mature spermatozoa are seen in the cauda epididymis

abnormal male meiosis ( J:338159 )

♂ • spermatocytes show chromosome misalignment on the metaphase plate (metaphase I)

♂ • meiotic cell cycle is delayed from early to mid/late pachytene from P14 to P18

♂ • however, no obvious alternations are seen in double-strand DNA break repair, synapse formation, or crossover formation in spermatocytes

increased male germ cell apoptosis ( J:338159 )

♂ • apoptosis is increased in testes; most apoptotic cells are metaphase spermatocytes in stage XI-XII tubules, and some in stage I-III tubules