Phenotypes associated with this allele

• Allele Symbol: Tbl1xr1^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7514121
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ighg1^tm1(cre)Cgn/Ighg1^+ Tbl1xr1^tm1c(EUCOMM)Hmgu/Tbl1xr1^tm1c(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550774
cn2	Cd19^tm1(cre)Cgn/Cd19^+ Tbl1xr1^tm1c(EUCOMM)Hmgu/Tbl1xr1^tm1c(EUCOMM)Hmgu Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:7550775

Genotype
MGI:7550774

cn1

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Tbl1xr1^{tm1c(EUCOMM)Hmgu}/Tbl1xr1^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

Genotype
MGI:7550775

cn2

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Tbl1xr1^{tm1c(EUCOMM)Hmgu}/Tbl1xr1^{tm1c(EUCOMM)Hmgu}; Tg(Vav-BCL2)69Jad/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

hematopoietic system

abnormal lymphocyte morphology ( J:292118 )

• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically

abnormal B cell differentiation ( J:292118 )

• increased number of B220- cells, expressing more CD138 when immunized periodically

• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically

• normal mature B cell numbers in bone marrow when immunized periodically

abnormal spleen morphology ( J:292118 )

• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically

immune system

abnormal lymphocyte morphology ( J:292118 )

• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically

abnormal B cell differentiation ( J:292118 )

• increased number of B220- cells, expressing more CD138 when immunized periodically

• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically

• normal mature B cell numbers in bone marrow when immunized periodically

abnormal spleen morphology ( J:292118 )

• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically

mortality/aging

premature death ( J:292118 )

• when immunized periodically

neoplasm

increased organ/body region tumor incidence ( J:292118 )

• in kidney, lung, liver, intestines and other organs when immunized periodically