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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syt13tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7514187
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Syt13tm1c(EUCOMM)Hmgu/Syt13tm1c(EUCOMM)Hmgu
Tg(Neurog3-cre)C1Able/0 		involves: C57BL/6J * C57BL/6N MGI:7751428
cn2
 		Ins1tm1.1(cre)Thor/Ins1+
Syt13tm1c(EUCOMM)Hmgu/Syt13tm1c(EUCOMM)Hmgu 		involves: C57BL/6J * C57BL/6N MGI:7751429


Genotype
MGI:7751428
cn1
Allelic
Composition		 Syt13tm1c(EUCOMM)Hmgu/Syt13tm1c(EUCOMM)Hmgu
Tg(Neurog3-cre)C1Able/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syt13tm1c(EUCOMM)Hmgu mutation (0 available); any Syt13 mutation (22 available)
Tg(Neurog3-cre)C1Able mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal endocrine pancreas development ( J:327292 )
• mice show impaired endocrine cell egression, with pancreata islets in more direct connection with the epithelial cells
• pancreas shows an increase in the alpha to beta cell ratio




Genotype
MGI:7751429
cn2
Allelic
Composition		 Ins1tm1.1(cre)Thor/Ins1+
Syt13tm1c(EUCOMM)Hmgu/Syt13tm1c(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1.1(cre)Thor mutation (4 available); any Ins1 mutation (46 available)
Syt13tm1c(EUCOMM)Hmgu mutation (0 available); any Syt13 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:327292 )
N
• mice show normal endocrine cell egression and normal numbers of pancreatic alpha and beta cells




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory