Phenotypes associated with this allele

• Allele Symbol: Syt13^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7514188
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt13^tm1d(EUCOMM)Hmgu/Syt13^tm1d(EUCOMM)Hmgu	involves: C57BL/6J * C57BL/6N	MGI:7751427

Genotype
MGI:7751427

hm1

• Allelic Composition: Syt13^{tm1d(EUCOMM)Hmgu}/Syt13^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:327292 )

• lethality at early postnatal stages with no mice obtained at P21, but normal numbers at E18.5

endocrine/exocrine glands

abnormal endocrine pancreas development ( J:327292 )

• alternations in epithelial organization of the pancreas start to be seen at E14.5

• pancreas contains a multi-layer epithelium rather than the normal single-layer of Foxa2^low cells, with the additional layers consisting mostly of Foxa2^high cells and are negative for the ductal cell marker Sox9, indicating a defect during endocrine lineage acquisition

• pancreas shows an increased number of retained endocrine progenitor/endocrine precursor/endocrine cells (Nkx6-1^high/Sox9-) within the epithelium

• pancreas shows an increased direct attachment between proto-islets and the epithelium, indicating impaired endocrine cell egression

• the typical proto-islet rearrangement, in which alpha cells are at the periphery and beta cells at the core, are disrupted in pancreas

• pancreas exhibits an increase in the number of alpha cells at the expense of beta cells at E14.5-E18.5, indicating a shift in beta- to alpha-cell fate

• however pancreatic epithelium is normal at E12.5 and E13.5 and ductal and acinar differentiation and morphogenesis are normal