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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card19tm1Rwen
targeted mutation 1, Renren Wen
MGI:7514948
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card19tm1Rwen/Card19tm1Rwen involves: 129P2/OlaHsd * C57BL/6 MGI:7514949
cx2
 		Card19tm1Rwen/Card19tm1Rwen
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:7514984
cx3
 		Card19tm1Rwen/Card19tm1Rwen
Tg(IghelMD4)4Ccg/0
Tg(ML5sHEL)5Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JSfd MGI:7514963


Genotype
MGI:7514949
hm1
Allelic
Composition		 Card19tm1Rwen/Card19tm1Rwen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card19tm1Rwen mutation (0 available); any Card19 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:336763 )
N
• despite expression profile populations of macrophages, granulocytes, erythrocytes, and natural killer cells in the bone marrow or spleens are similar to wild-type controls
decreased autoantibody level ( J:336763 )
• decrease in self-reactive IgM and IgG at 2 months of age compared to wild-type controls
• in culture single splenic B cells from 2 month old mice produce fewer self-reactive B cells




Genotype
MGI:7514984
cx2
Allelic
Composition		 Card19tm1Rwen/Card19tm1Rwen
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card19tm1Rwen mutation (0 available); any Card19 mutation (13 available)
Tg(IghelMD4)4Ccg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell activation ( J:336763 )
• BCR-induced IkappaBalpha phosporylation is increased in B cells

immune system
abnormal B cell activation ( J:336763 )
• BCR-induced IkappaBalpha phosporylation is increased in B cells




Genotype
MGI:7514963
cx3
Allelic
Composition		 Card19tm1Rwen/Card19tm1Rwen
Tg(IghelMD4)4Ccg/0
Tg(ML5sHEL)5Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JSfd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card19tm1Rwen mutation (0 available); any Card19 mutation (13 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(ML5sHEL)5Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:336763 )
• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation
decreased B cell proliferation ( J:336763 )
• self-reactive B-cells are less proliferative in response to BCR engagement
decreased B cell number ( J:336763 )
• decrease in the B cell population in the spleen indicating enhanced B cell tolerance
increased B cell number ( J:336763 )
• increase in the frequency of gamma L chain positive splenic B cells compared to transgenic mice wild-type for Card19

hematopoietic system
increased B cell apoptosis ( J:336763 )
• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation
decreased B cell proliferation ( J:336763 )
• self-reactive B-cells are less proliferative in response to BCR engagement
decreased B cell number ( J:336763 )
• decrease in the B cell population in the spleen indicating enhanced B cell tolerance
increased B cell number ( J:336763 )
• increase in the frequency of gamma L chain positive splenic B cells compared to transgenic mice wild-type for Card19

cellular
increased B cell apoptosis ( J:336763 )
• increased apoptosis of B cells in response to self-antigen HEL or anti-IgM stimulation
decreased B cell proliferation ( J:336763 )
• self-reactive B-cells are less proliferative in response to BCR engagement




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory