Phenotypes associated with this allele

• Allele Symbol: Septin14^em1.1Plk
• Allele Name: endonuclease-mediated mutation 1.1, Pao-Lin Kuo
• Allele ID: MGI:7517009
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Septin14^em1.1Plk/Septin14^em1.1Plk	involves: C57BL/6 * CBA	MGI:7517013

Genotype
MGI:7517013

hm1

• Allelic Composition: Septin14^em1.1Plk/Septin14^em1.1Plk
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced passive avoidance behavior ( J:338866 )

♂ • increased latency to enter the dark compartment in males but not females compared to wild-type controls

impaired cued conditioning behavior ( J:338866 )

• appear to show dampened observation fear (vanilla scent) induced conditioning magnitude in both males and females

increased thigmotaxis ( J:338866 )

• spend less time in the lighted center in an open field

nervous system

increased neuronal stem cell self-renewal ( J:338866 )

• increased proliferation in ventral but not dorsal hippocampal dentate gyrus in both males and females