Phenotypes associated with this allele

• Allele Symbol: Mplkip^em2Nimo
• Allele Name: endonuclease-mediated mutation 2, Nima Mosammaparast
• Allele ID: MGI:7518887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mplkip^em2Nimo/Mplkip^em2Nimo	C57BL/6-Mplkip^em2Nimo	MGI:7519037

Genotype
MGI:7519037

hm1

• Allelic Composition: Mplkip^em2Nimo/Mplkip^em2Nimo
• Genetic Background: C57BL/6-Mplkip^em2Nimo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:338438 )

N • normal behavior in marble burying test

N • normal acoustic startle reflex

abnormal depression-related behavior ( J:338438 )

• reduced swimming speed in cued and place trials of the Morris water maze test

abnormal fear/anxiety-related behavior ( J:338438 )

• reduced freezing levels on auditory cue component in the fear conditioning test

• normal behavior in baseline or tone-shock training, contextual fear test and altered context baseline components in the fear conditioning tes

• normal shock sensitivity in the fear conditioning test

abnormal motor capabilities/coordination/movement ( J:338438 )

• greater latency to leave small, circumscribed area in walking initiation test

• reduced swimming speed in cued and place trials of the Morris water maze test

abnormal motor coordination/balance ( J:338438 )

• shorter latency to fall in accelerating rotarod test

• normal behavior in stationary or constant speed rotarod test

increased locomotor activity ( J:338438 )

• greater distance traveled in periphery in open field test

• normal locomotor activity in 1-h locomotor activity, ledge platform, pole, 60 and 90 degree inclined and inverted screen tests

mortality/aging

mortality/aging ( J:338438 )

N • normal lifespan

prenatal lethality, incomplete penetrance ( J:338438 )

• mice born at lower-than-expected Mendelian ratio

growth/size/body

slow postnatal weight gain ( J:338438 )

integument

sparse hair ( J:338438 )

• in aged mice

nervous system

nervous system phenotype ( J:338438 )

N • normal prepulse inhibition in males and females

N • normal brain size in females

decreased brain size ( J:338438 )

♂ • small brains in males

♂ • normal brain size in females