Phenotypes associated with this allele

• Allele Symbol: Il1r1^em1Qizh
• Allele Name: endonuclease-mediated mutation 1, Qing Zhou
• Allele ID: MGI:7519061
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1r1^em1Qizh/Il1r1^em1Qizh	C57BL/6-Il1r1^em1Qizh	MGI:7519087

Genotype
MGI:7519087

hm1

• Allelic Composition: Il1r1^em1Qizh/Il1r1^em1Qizh
• Genetic Background: C57BL/6-Il1r1^em1Qizh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interleukin-6 level ( J:338375 )

• in collagen antibody-induced arthritis (CAIA) experiments

increased circulating tumor necrosis factor level ( J:338375 )

• in collagen antibody-induced arthritis (CAIA) experiments

immune system

increased circulating interleukin-6 level ( J:338375 )

• in collagen antibody-induced arthritis (CAIA) experiments

increased circulating tumor necrosis factor level ( J:338375 )

• in collagen antibody-induced arthritis (CAIA) experiments

increased susceptibility to induced arthritis ( J:338375 )

• severe and persistent arthritis in collagen antibody-induced arthritis (CAIA) experiments as evidenced by bone erosion and inflammatory cell invasion and articular erosion in ankle joints

skeleton

increased susceptibility to induced arthritis ( J:338375 )

• severe and persistent arthritis in collagen antibody-induced arthritis (CAIA) experiments as evidenced by bone erosion and inflammatory cell invasion and articular erosion in ankle joints