Analysis Tools|
Allele Symbol Allele Name Allele ID |
Septin2tm1c(EUCOMM)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:7520266 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while the abundance of SEPTIN2 is markedly reduced in sciatic nerve lysates as expected, the abundance of other septin subunits expressed in PNS myelin (SEPTIN7, SEPTIN8, SEPTIN9, and SEPTIN11) is also substantially lower than that in sciatic nerve lysates of control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• P14 sciatic nerves show no significant change in the number of normal-appearing myelinated axons; no axonal degeneration is noted and the number of myelin outfoldings is similar to that in control mice, indicating normal biogenesis of PNS myelin
• P75 sciatic nerves show similar abundance of myelin proteins (MAG, CNP, P0/MPZ, PMP22) relative to control mice
• motor nerve conduction velocity (mNCV) in sciatic nerves and sensory nerve conduction velocity (sNCV) in the tail nerve are slightly but not significantly decreased at 1 year of age
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• while the abundance of SEPTIN2 is markedly reduced in sciatic nerve lysates as expected, the abundance of other septin subunits expressed in PNS myelin (SEPTIN7, SEPTIN8, SEPTIN9, and SEPTIN11) is also substantially lower than that in the sciatic nerve lysates of control mice
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• mice show no alterations in the latency of retracting a hindpaw upon a mechanical stimulus (plantar test) at 32 weeks of age or in the latency of falling from an accelerating rotating rod at 6 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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