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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pnp2em1Smoc
endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI:7520368
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pnp2em1Smoc/Pnp2em1Smoc C57BL/6J-Pnp2em1Smoc MGI:7716949
cx2
 		Miga2tm1a(KOMP)Wtsi/Miga2tm1a(KOMP)Wtsi
Pnp2em1Smoc/Pnp2em1Smoc 		C57BL/6-Miga2tm1a(KOMP)Wtsi Pnp2em1Smoc MGI:7716953


Genotype
MGI:7716949
hm1
Allelic
Composition		 Pnp2em1Smoc/Pnp2em1Smoc
Genetic
Background		 C57BL/6J-Pnp2em1Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnp2em1Smoc mutation (1 available); any Pnp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:339075 )
N
• mice do not exhibit any obvious dysfunction of T lymphocyte development or maturation




Genotype
MGI:7716953
cx2
Allelic
Composition		 Miga2tm1a(KOMP)Wtsi/Miga2tm1a(KOMP)Wtsi
Pnp2em1Smoc/Pnp2em1Smoc
Genetic
Background		 C57BL/6-Miga2tm1a(KOMP)Wtsi Pnp2em1Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Miga2tm1a(KOMP)Wtsi mutation (2 available); any Miga2 mutation (36 available)
Pnp2em1Smoc mutation (1 available); any Pnp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:339075 )
• CD4+ T cells grown in culture show partial normalization of the hyperproduction of xanthine that is seen in single Miga2tm1a(KOMP)Wtsi homozygotes but still greater than in wild-type mice

immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:339075 )
• CD4+ T cells grown in culture show partial normalization of the hyperproduction of xanthine that is seen in single Miga2tm1a(KOMP)Wtsi homozygotes but still greater than in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory