Phenotypes associated with this allele

• Allele Symbol: Smarcb1^em1Koke
• Allele Name: endonuclease-mediated mutation 1, Kornelius Kerl
• Allele ID: MGI:7520876
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smarcb1^em1Koke/Smarcb1^em1Koke	C57BL/6-Smarcb1^em1Koke	MGI:7520938

Genotype
MGI:7520938

hm1

• Allelic Composition: Smarcb1^em1Koke/Smarcb1^em1Koke
• Genetic Background: C57BL/6-Smarcb1^em1Koke

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:337790 )

N • normal thalamus and cerebellum morphology at age P35-40

N • normal brain size at age P35-40

N • normal choroid plexus, ependyma and cerebellum morphology at age 4-8 weeks

N • normal brain at age P0 and in E13.5 embryos

obstructive hydrocephaly ( J:337790 )

• in 60% of mice by age P50

cerebral aqueductal stenosis ( J:337790 )

• at age P35-40

enlarged brain ventricles ( J:337790 )

• several-fold increase in absolute and relative ventricle volume at age 4-8 weeks and P35-40

dilated lateral ventricle ( J:337790 )

• at age P35-40

thin cerebral cortex ( J:337790 )

• at age 4-8 weeks

embryo

embryo phenotype ( J:337790 )

N • mice born at expected Mendelian ratios

growth/size/body

slow postnatal weight gain ( J:337790 )

• 35% lighter at age P30 to 21% lighter at age P40

neoplasm

neoplasm ( J:337790 )

N • no tumor formation in brain at age 4-8 weeks

cellular

cellular phenotype ( J:337790 )

N • no sites of cellular hyperproliferation in brain at age 4-8 weeks