digestive/alimentary system
• mice exhibit exacerbated DSS-induced colitis, with mice losing more weight, shorter colon lengths, greater inflammatory cell infiltration and epithelial cell destruction
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
• mice with DSS-induced colitis show alleviation of colitis following treatment with recombinant mouse IL17B
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homeostasis/metabolism
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
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hematopoietic system
• mice with DSS-induced colitis show an altered colonic immune cell composition compared to wild-type mice with colitis, with an increase in CD11B+Ly6Ghigh neutrophil infiltration in colon lamina propria
• mice with DSS-induced colitis treated with recombinant mouse IL17B show inhibition of S100a9+ neutrophil infiltration in the colon
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• colonic macrophages of mice with DSS-induced colitis show increased inflammatory response with increased production of inflammatory cytokines
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immune system
• mice exhibit exacerbated DSS-induced colitis, with mice losing more weight, shorter colon lengths, greater inflammatory cell infiltration and epithelial cell destruction
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
• mice with DSS-induced colitis show alleviation of colitis following treatment with recombinant mouse IL17B
|
• mice with DSS-induced colitis show an altered colonic immune cell composition compared to wild-type mice with colitis, with an increase in CD11B+Ly6Ghigh neutrophil infiltration in colon lamina propria
• mice with DSS-induced colitis treated with recombinant mouse IL17B show inhibition of S100a9+ neutrophil infiltration in the colon
|
• colonic macrophages of mice with DSS-induced colitis show increased inflammatory response with increased production of inflammatory cytokines
|
• levels of inflammatory cytokines TNF, IL1B, and IL6 are increased in colon in mice with DSS-induced colitis
|