Phenotypes associated with this allele

• Allele Symbol: Vgll3^em1Nakm
• Allele Name: endonuclease-mediated mutation 1, Michio Nakaya
• Allele ID: MGI:7524740
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vgll3^em1Nakm/Vgll3^em1Nakm	C57BL/6N-Vgll3^em1Nakm	MGI:7524749

Genotype
MGI:7524749

hm1

• Allelic Composition: Vgll3^em1Nakm/Vgll3^em1Nakm
• Genetic Background: C57BL/6N-Vgll3^em1Nakm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to myocardial ischemic injury ( J:339852 )

• myocardial infarction-induced cardiac fibrosis is attenuated, with collagen production by myofibroblasts isolated from myocardial infracted hearts is reduced compared to controls

• myocardial infarction-induced cardiac function is improved compared to controls, showing increased ejection fraction and fractional shortening rating (improved contractility) and decreased E/A ratio, indicating reduced diastolic function

homeostasis/metabolism

decreased susceptibility to myocardial ischemic injury ( J:339852 )

• myocardial infarction-induced cardiac fibrosis is attenuated, with collagen production by myofibroblasts isolated from myocardial infracted hearts is reduced compared to controls

• myocardial infarction-induced cardiac function is improved compared to controls, showing increased ejection fraction and fractional shortening rating (improved contractility) and decreased E/A ratio, indicating reduced diastolic function