All Phenotypes Polr1a<em1Knwea> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Polr1a^em1Knwea
endonuclease-mediated mutation 1, Kathryn Nicole Weaver
MGI:7526140

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr1a^em1Knwea/Polr1a^em1Knwea	C57BL/6-Polr1a^em1Knwea	MGI:7526443
ht2	Polr1a^em1Knwea/Polr1a⁺	C57BL/6-Polr1a^em1Knwea	MGI:7526438
cn3	Foxg1^{tm1.1(cre)Ddmo}/0 Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526484
cn4	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:7526471
cn5	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA	MGI:7526470

Allelic Composition	Polr1a^em1Knwea/Polr1a^em1Knwea
Genetic Background	C57BL/6-Polr1a^em1Knwea

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Polr1a^em1Knwea/Polr1a⁺
Genetic Background	C57BL/6-Polr1a^em1Knwea

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:335489 )

N	• mice born at expected Mendelian ratios and normal sex ratio

growth/size/body

growth/size/body region phenotype ( J:335489 )

N	• no obvious phenotype

reproductive system

reproductive system phenotype ( J:335489 )

• fertile

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/0 Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (29 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E14 and E17 embryos

• normal in E12 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

craniofacial

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N	• normal outflow tract septation in E12 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in some E14-E15 embryos

growth/size/body

midline cleft upper lip ( J:335489 )

• median lip notches in some E14-E15 embryos

cleft palate ( J:335489 )

• in some E14-E15 embryos

facial cleft ( J:335489 )

• in some E14-E15 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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