All Phenotypes Polr1a<tm1d(EUCOMM)Hmgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Polr1a^{tm1d(EUCOMM)Hmgu}
targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI:7526217

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1d(EUCOMM)Hmgu}	involves: C57BL/6N	MGI:7526458
ht2	Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a⁺	involves: C57BL/6N	MGI:7526455
ht3	Polr1a^em2Knwea/Polr1a^{tm1d(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N	MGI:7526448
ht4	Polr1a^em3Knwea/Polr1a^{tm1d(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N	MGI:7526451
cn5	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	MGI:7526488
cn6	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526477
cn7	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526462
cn8	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	MGI:7526466

Allelic Composition	Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1d(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:335489 )

• mice born at expected Mendelian ratios and sex ratios

growth/size/body

growth/size/body region phenotype ( J:335489 )

• no obvious phenotype

reproductive system

reproductive system phenotype ( J:335489 )

• fertile

Allelic Composition	Polr1a^em2Knwea/Polr1a^{tm1d(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^em2Knwea mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:335489 )

• mice born at expected Mendelian ratios and sex ratios

growth/size/body

growth/size/body region phenotype ( J:335489 )

• no obvious phenotype

Allelic Composition	Polr1a^em3Knwea/Polr1a^{tm1d(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr1a^em3Knwea mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:335489 )

• mice born at expected Mendelian ratios and sex ratios

growth/size/body

growth/size/body region phenotype ( J:335489 )

• no obvious phenotype

Allelic Composition	Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^{tm1.1(cre)Ddmo} mutation (1 available); any Foxg1 mutation (29 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

telencephalon hypoplasia ( J:335489 )

• in E12, E14 and E17 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (94 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:335489 )

• in E12 embryos

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

heart right ventricle hypoplasia ( J:335489 )

• in E12 embryos

abnormal heart right ventricle outflow tract morphology ( J:335489 )

• shorter in E10 embryos

absent heart right ventricle ( J:335489 )

• newborn hearts have only single ventricle

growth/size/body

enlarged heart ( J:335489 )

• in newborns, owing to blood pooling

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:335489 )

• normal outflow tract septation in E9.5 embryos

craniofacial

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

digestive/alimentary system

cleft palate ( J:335489 )

• in E16 and E17 embryos

growth/size/body

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft palate ( J:335489 )

• in E16 and E17 embryos

facial cleft ( J:335489 )

• in E16 and E17 embryos

respiratory system

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

skeleton

frontal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

temporal bone squamous part hypoplasia ( J:335489 )

• in E16 and E17 embryos

cleft chin ( J:335489 )

• mandibular cleft in E14-E17 embryos

short mandible ( J:335489 )

• in E17 embryos

nasal bone hypoplasia ( J:335489 )

• in E16 and E17 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24