Phenotypes associated with this allele

• Allele Symbol: Cfap57^em1Qsh
• Allele Name: endonuclease-mediated mutation 1, Qinghua Shi
• Allele ID: MGI:7529021
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfap57^em1Qsh/Cfap57^em1Qsh	C57BL/6-Cfap57^em1Qsh	MGI:7529045

Genotype
MGI:7529045

hm1

• Allelic Composition: Cfap57^em1Qsh/Cfap57^em1Qsh
• Genetic Background: C57BL/6-Cfap57^em1Qsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:333969 )

N • normal testicular size and testes-to-body-weight ratio

abnormal sperm flagellum morphology ( J:333969 )

abnormal sperm axoneme morphology ( J:333969 )

• disorganized structure

• mis-assembly of inner dynein arms (IDAs)

• normal 9+2 arrangement

coiled sperm flagellum ( J:333969 )

kinked sperm flagellum ( J:333969 )

short sperm flagellum ( J:333969 )

oligozoospermia ( J:333969 )

• 95% reduced sperm numbers in epididymis

• reduced spermatid and spermatozoa numbers in testes

immotile sperm ( J:333969 )

male infertility ( J:333969 )

cellular

abnormal sperm flagellum morphology ( J:333969 )

abnormal sperm axoneme morphology ( J:333969 )

• disorganized structure

• mis-assembly of inner dynein arms (IDAs)

• normal 9+2 arrangement

coiled sperm flagellum ( J:333969 )

kinked sperm flagellum ( J:333969 )

short sperm flagellum ( J:333969 )

oligozoospermia ( J:333969 )

• 95% reduced sperm numbers in epididymis

• reduced spermatid and spermatozoa numbers in testes

immotile sperm ( J:333969 )

growth/size/body

growth/size/body region phenotype ( J:333969 )

N • normal growth and development

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:333969