Phenotypes associated with this allele

• Allele Symbol: Cirpil^em1Zpan
• Allele Name: endonuclease-mediated mutation 1, Zhenwei Pan
• Allele ID: MGI:7529393
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cirpil^em1Zpan/Cirpil^em1Zpan	C57BL/6-Cirpil^em1Zpan	MGI:7529457

Genotype
MGI:7529457

hm1

• Allelic Composition: Cirpil^em1Zpan/Cirpil^em1Zpan
• Genetic Background: C57BL/6-Cirpil^em1Zpan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased susceptibility to myocardial ischemic injury ( J:339952 )

• mice show exacerbated cardiac ischemia/reperfusion injury, with a greater decrease in ejection fraction and fractional shortening, a greater infarct area to area at risk ratio, higher serum creatine kinase and lactate dehydrogenase (LDH) levels, greater level of apoptosis

• however, echocardiography shows no difference in the function of hearts at 8 weeks of age

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:339952 )

• mice show exacerbated cardiac ischemia/reperfusion injury, with a greater decrease in ejection fraction and fractional shortening, a greater infarct area to area at risk ratio, higher serum creatine kinase and lactate dehydrogenase (LDH) levels, greater level of apoptosis

• however, echocardiography shows no difference in the function of hearts at 8 weeks of age